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] Chronic Idiopathic Urticaria. Two 4-week, multicenter, randomized, double-blind, placebo-controlled clinical trials compared four different doses of fexofenadine hydrochloride tablet (20, 60, 120, and 240 mg cuscuzeira tramontina allegra inox jewelry daily) to placebo 120 robinson road 06/012d allegra subjects aged 12 to 70 years with chronic idiopathic urticaria (n726). Efficacy was demonstrated by a significant reduction in mean pruritus scores (MPS), mean number of wheals (MNW), and mean total symptom scores (MTSS, the sum of the MPS and MNW score). Although all 4 doses were significantly superior to placebo, symptom reduction was greater and efficacy was maintained over the entire 4-week treatment period with fexofenadine hydrochloride doses of ge;60 mg twice daily. However, no additional benefit of the 120 or 240 mg fexofenadine hydrochloride twice daily dose was seen over the 60 mg twice daily dose in reducing symptom scores. There were no significant differences in the effect of fexofenadine hydrochloride across subgroups of subjects defined by gender, age, weight, and race.

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VALĂRIO, A. ; WATZLAWICK, Luciano Farinha ; Balbinot, R. ; Caldeira, M. ; FIGUEIREDO FILHO, A.

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