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P values of less than 0. 05 from two-sided tests were considered to indicate statistical significance. The statistical software packages STATA (version 10. 0) (StataCorp) and SAS (version 9. 1 for Windows) (SAS Institute) were used. Baseline characteristics of the entire sample and of the participants who did not have cardiovascular disease at baseline are shown in Table 1 Table 1 Baseline Characteristics of the Study Cohort. The mean age at baseline was 71. 0 years (range, 69. 4 to 73.

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After 254 nm UVC irradiation, only 6-9 of the base substitutions were at dipyrimidines containing 5-methylcytosine. However, 24-32 of the solar light-induced mutations were at dipyrimidines that contain 5-methylcytosine and most of these mutations were transitions. Thus, CPDs forming preferentially at dipyrimidines with 5-methylcytosine are responsible for a considerable fraction of the mutations induced by sunlight in mammalian cells.

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